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Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates

https://doi.org/10.1021/acsami.8b17733

Cross, Lauren M.; Carrow, James K.; Ding, Xicheng; Singh, Kanwar Abhay; Gaharwar, Akhilesh K. (January 2019, ACS Applied Materials & Interfaces)

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3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering

https://doi.org/10.1093/rb/rby024

Carrow, James K; Di Luca, Andrea; Dolatshahi-Pirouz, Alireza; Moroni, Lorenzo; Gaharwar, Akhilesh K (December 2018, Regenerative Biomaterials)

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Nanoengineered injectable hydrogels for wound healing application

https://doi.org/10.1016/j.actbio.2018.01.045

Lokhande, Giriraj; Carrow, James K.; Thakur, Teena; Xavier, Janet R.; Parani, Madasamy; Bayless, Kayla J.; Gaharwar, Akhilesh K. (April 2018, Acta Biomaterialia)

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Nanoengineered Ionic–Covalent Entanglement (NICE) Bioinks for 3D Bioprinting

https://doi.org/10.1021/acsami.7b19808

Chimene, David; Peak, Charles W.; Gentry, James L.; Carrow, James K.; Cross, Lauren M.; Mondragon, Eli; Cardoso, Guinea B.; Kaunas, Roland; Gaharwar, Akhilesh K. (March 2018, ACS Applied Materials & Interfaces)

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Self‐assembled, ellipsoidal polymeric nanoparticles for intracellular delivery of therapeutics

https://doi.org/10.1002/jbm.a.36400

Desai, Prachi; Venkataramanan, Anjana; Schneider, Rebecca; Jaiswal, Manish K.; Carrow, James K.; Purwada, Alberto; Singh, Ankur; Gaharwar, Akhilesh K. (April 2018, Journal of Biomedical Materials Research Part A)

Abstract Nanoparticle shape has emerged as a key regulator of nanoparticle transport across physiological barriers, intracellular uptake, and biodistribution. We report a facile approach to synthesize ellipsoidal nanoparticles through self‐assembly of poly(glycerol sebacate)‐co‐poly(ethylene glycol) (PGS‐co‐PEG). The PGS‐PEG nanoparticle system is highly tunable, and the semiaxis length of the nanoparticles can be modulated by changing PGS‐PEG molar ratio and incorporating therapeutics. As both PGS and PEG are highly biocompatible, the PGS‐co‐PEG nanoparticles show high hemo‐, immuno‐, and cytocompatibility. Our data suggest that PGS‐co‐PEG nanoparticles have the potential for use in a wide range of biomedical applications including regenerative medicine, stem cell engineering, immune modulation, and cancer therapeutics. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2048–2058, 2018.
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